Endocrine Abstracts

Background: Alopecia areata is a common non-endocrine manifestation in autoimmune polyendocrine syndromes (APS). Alopecia universalis is its most severe form with total loss of scalp and body hair. Several attempts at classifications for multiple combinations of autoimmune disorders in APS were proposed. Type 1 diabetes is associated with epilepsy due to glycemic extremes and microvascular damage, but a shared etiology mediated by anti-glutamic acid decarboxylase antibodies (a...

Introduction: After gastric bypass, gastric secretion decreased and resorption of minerals and vitamins may be compromised. Lower resorpion of serum calcium and vitamin D could stimulate PTH secretion after restictive and malabsorptive bariatric procedures.Methods: We have measured serum calcium, D vitamin and PTH in patients (n=50, 17 males and 33 females) 6 and 12 months after R en Y gastric bypass, 38.6±12.6 years of age, with BMI 43&#17...

Introduction: By using insulin analogue, it is expected to improve glycemic regulation in poorly controlled type 2 diabetes (t2DM). The aim of the study was to examine the quality of glycemic control and quality of life (QoL) of patients managed with insulin analogues, previously treated with human insulin.Materials and methods: The pilot study included 30 t2DM outpatients, divided into two groups (15 subjects) – the first group was treated with hum...

Introduction: Relative adrenal insufficiency (RAI) is common in critically ill patients and is characterized by the normal adrenal reserve for homeostatic demands and inadequate cortisol response in acute stress situations. RAI can also occur in patients with liver cirrhosis, both compensated and decompensated. However, it is often forgotten and difficult to diagnose due to the overlap between clinical symptoms of adrenal insufficiency and decompensated liver disease. Also, hy...

A 34-year-old woman was initially presented with clinical signs of Cushing’s syndrome (CS). On endocrinological examination, a diagnosis of ACTH dependent CS was established (serum cortisol: 08.00 h: 1245 nmol/l; 24.00 h: 275; plasma ACTH concentration 104 ng/l; inadequate cortisol suppresion on LDDST (787) and suppresion to 318 following HDDST). A magnetic resonance imaging (MRI) confirmed a microadenoma in the left part of the pituitary. Ultrasound examination confirmed...

Some hematologic malignancies might increase the risk of fractures due to intrinsic factors of the disease but also because of the treatment with steroids or chemotherapy. The direct impact of novel targeted agents on the development of osteoporosis in these patients has not been recognized yet. A 64-years old female patient with B-cell chronic lymphocytic leukemia (B-CLL) has been followed for four years with no other comorbidities. In order to measure the burden of the disea...

Background: The differential diagnosis of the polyuria-polydipsia syndrome is challenging. The water-deprivation test is the current gold standard, but the test is cumbersome, and the diagnostic performance is poor. Copeptin, which is a split product of the vasopressin pre-propeptide, appears to be a robust biomarker in the circulation and a promising tool for the diagnosis of patients with polyuria and polydipsia, especially when measured in conjunction with intravenous infus...

The most common cause of primary hypothyroidism is Hashimoto’s disease, while the most common cause of hyperthyroidism is Graves’ disease; both conditions are autoimmune diseases. In clinical practice, the switch from hypothyroidism to hyperthyroidism is a rare phenomenon. So far, the etiology and mechanisms of conversion have not been determined. We present a case where we believe the monoclonal antibody rituximab was the primary cause of transition. A 58-year-old m...

Background: Several clinical features of chronic liver disease, such as sarcopenia, anaemia, low bone mass and gynecomastia are similar as manifestation of hypogonadism. Decreased testosterone levels are common in patients with severe liver disease and are associated with worse clinical outcomes and mortality.Case Presentation: A 33-year-old patient was admitted to the hospital due to severe alcoholic hepatitis. He was in poor general condition, icteric,...

Background and aims: After two decades of silence in classification system od type 2 diabetes there are some indices that the dibebtic retinopathy might be the sign for introduction of insulin therapy. The aim of this study was to examine associations between measures of diabetic foot in people with diabetes complicated by nonproliferative retinopathy (NPDR), maculopathy and proliferative retinopathy (PDR).Materials and methods: People were included had ...